Details

Autor(en) / Beteiligte

• Cai, Wanwan
• Zhou, Wanbang
• Han, Zhe
• Lei, Junrong
• Zhuang, Jian
• Zhu, Ping
• Wu, Xiushan
• Yuan, Wuzhou

Titel

Master regulator genes and their impact on major diseases

Ist Teil von

• PeerJ (San Francisco, CA), 2020-10, Vol.8, p.e9952-e9952, Article e9952

Ort / Verlag

San Diego: PeerJ. Ltd

Erscheinungsjahr

2020

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Master regulator genes (MRGs) have become a hot topic in recent decades. They not only affect the development of tissue and organ systems but also play a role in other signal pathways by regulating additional MRGs. Because a MRG can regulate the concurrent expression of several genes, its mutation often leads to major diseases. Moreover, the occurrence of many tumors and cardiovascular and nervous system diseases are closely related to MRG changes. With the development in omics technology, an increasing amount of investigations will be directed toward MRGs because their regulation involves all aspects of an organism’s development. This review focuses on the definition and classification of MRGs as well as their influence on disease regulation.