International journal of molecular sciences, 2021-10, Vol.22 (21), p.11533
2021
Details
- Autor(en) / Beteiligte
- Titel
- The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies
- Ist Teil von
- International journal of molecular sciences, 2021-10, Vol.22 (21), p.11533
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Thiazolidin-4-ones is an important heterocyclic ring system of a pharmacophore and a privileged scaffold in medicinal chemistry. This review is focused on the latest scientific reports regarding biological activities of thiazolidin-4-ones published in 2020 and 2021. The review covers recent information about antioxidant, anticancer, anti-inflammatory, analgesic, anticonvulsant, antidiabetic, antiparasitic, antimicrobial, antitubercular and antiviral properties of thiazolidin-4-ones. Additionally, the influence of different substituents in molecules on their biological activity was discussed in this paper. Thus, this study may help to optimize the structure of thiazolidin-4-one derivatives as more efficient drug agents. Presented information may be used as a practical hint for rational design of new small molecules with biological activity, especially among thiazolidin-4-ones.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms222111533Titel-ID: cdi_doaj_primary_oai_doaj_org_article_a6995943bf8f46cea6b9557cba82c1ca
- Format
- –
- Schlagworte
- Alzheimer's disease, Analgesics, Analgesics - chemistry, Analgesics - pharmacology, Animals, Anti-Infective Agents - chemistry, Anti-Infective Agents - pharmacology, anti-inflammatory activity, Anti-Inflammatory Agents - chemistry, Anti-Inflammatory Agents - pharmacology, anticancer activity, Anticonvulsants, Anticonvulsants - chemistry, Anticonvulsants - pharmacology, antidiabetic activity, Antidiabetics, Antiinfectives and antibacterials, Antineoplastic Agents - chemistry, Antineoplastic Agents - pharmacology, antioxidant activity, Antioxidants, Antioxidants - chemistry, Antioxidants - pharmacology, antiparasitic activity, Antiparasitic agents, Antiviral activity, Biological activity, Cancer, Diabetes mellitus, Enzymes, Free radicals, Humans, Hypoglycemic Agents - chemistry, Hypoglycemic Agents - pharmacology, Inflammation, Ligands, Lipid peroxidation, Lipids, Molecular Structure, Mortality, Neuroprotective Agents - chemistry, Neuroprotective Agents - pharmacology, Review, Reviews, Structure-Activity Relationship, thiazolidine-4-ones, Thiazolidines - chemistry, Thiazolidines - pharmacology, Vascular endothelial growth factor, Vitamin C