Marine drugs, 2021-11, Vol.19 (12), p.659
2021
Details
- Autor(en) / Beteiligte
- Titel
- Omacor Protects Normotensive and Hypertensive Rats Exposed to Continuous Light from Increased Risk to Malignant Cardiac Arrhythmias
- Ist Teil von
- Marine drugs, 2021-11, Vol.19 (12), p.659
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Light pollution disturbs circadian rhythm, and this can also be deleterious to the heart by increased susceptibility to arrhythmias. Herein, we investigated if rats exposed to continuous light had altered myocardial gene transcripts and/or protein expression which affects arrhythmogenesis. We then assessed if Omacor supplementation benefitted affected rats. Male and female spontaneously hypertensive (SHR) and normotensive Wistar rats (WR) were housed under standard 12 h/12 h light/dark cycles or exposed to 6-weeks continuous 300 lux light for 24 h. Half the rats were then treated with 200 mg/100 g b.w. Omacor . Continuous light resulted in higher male rat vulnerability to malignant ventricular fibrillation (VF). This was linked with myocardial connexin-43 (Cx43) down-regulation and deteriorated intercellular electrical coupling, due in part to increased pro-inflammatory NF-κB and iNOS transcripts and decreased sarcoplasmic reticulum Ca ATPase transcripts. Omacor treatment increased the electrical threshold to induce the VF linked with amelioration of myocardial Cx43 mRNA and Cx43 protein levels and the suppression of NF-κB and iNOS. This indicates that rat exposure to continuous light results in deleterious cardiac alterations jeopardizing intercellular Cx43 channel-mediated electrical communication, thereby increasing the risk of malignant arrhythmias. The adverse effects were attenuated by treatment with Omacor , thus supporting its potential benefit and the relevance of monitoring omega-3 index in human populations at risk.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1660-3397eISSN: 1660-3397DOI: 10.3390/md19120659Titel-ID: cdi_doaj_primary_oai_doaj_org_article_a5444b06e0e549fba0948efa3fcbf064
- Format
- –
- Schlagworte
- Adenosine triphosphatase, Alzheimer's disease, Animals, Aquatic Organisms, Arrhythmias, Cardiac - complications, Arrhythmias, Cardiac - physiopathology, Arrhythmias, Cardiac - prevention & control, Biometrics, Blood pressure, Blood Pressure - drug effects, Cardiac arrhythmia, cardiac arrhythmias, Cardiac muscle, Circadian rhythm, Circadian rhythms, Communication, Connexin 43, Connexin 43 - metabolism, Dietary Supplements, Disease Models, Animal, Docosahexaenoic Acids - administration & dosage, Docosahexaenoic Acids - chemistry, Docosahexaenoic Acids - pharmacology, Drug Combinations, Eicosapentaenoic Acid - administration & dosage, Eicosapentaenoic Acid - chemistry, Eicosapentaenoic Acid - pharmacology, Exposure, Fatty acids, Female, Females, Fibrillation, Heart, Heart - drug effects, Human populations, Hypertension, Hypertension - complications, Inflammation, Kinases, Light, Light Pollution, Light sources, Male, Males, Melatonin, NF-κB, NF-κB protein, Nitric oxide, Nitric-oxide synthase, omacor, Plankton, Proteins, Rats, Rats, Inbred SHR, Rats, Wistar, Risk communication, Sarcoplasmic reticulum, Stress, Physiological, Supplements, Ventricle, Ventricular fibrillation, Vulnerability