Details

Autor(en) / Beteiligte

• Bogusz-Górna, Klaudia
• Polańska, Adriana
• Dańczak-Pazdrowska, Aleksandra
• Żaba, Ryszard
• Sumińska, Marta
• Fichna, Piotr
• Kędzia, Andrzej

Titel

Non-invasive detection of early microvascular changes in juveniles with type 1 diabetes

Ist Teil von

• Cardiovascular diabetology, 2023-10, Vol.22 (1), p.1-285, Article 285

Ort / Verlag

London: BioMed Central

Erscheinungsjahr

2023

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Abstract Aims/Hypothesis The study aimed to assess the usefulness of capillaroscopy and photoplethysmography in the search for early vascular anomalies in children with type 1 diabetes. Methods One hundred sixty children and adolescents aged 6–18, 125 patients with type 1 diabetes, and 35 healthy volunteers were enrolled in the study. We performed a detailed clinical evaluation, anthropometric measurements, nailfold capillaroscopy, and photoplethysmography. Results Patients with diabetes had more often abnormal morphology in capillaroscopy (68.60%, p  = 0.019), enlarged capillaries (32.6%, p  = 0.006), and more often more over five meandering capillaries (20.90%, p  = 0.026) compared to healthy controls. Meandering capillaries correlated with higher parameters of nutritional status. In a photoplethysmography, patients with diagnosed neuropathy had a higher percentage of flow disturbance curves ( p  < 0.001) with a reduced frequency of normal curves ( p  = 0.050). Conclusions Capillaroscopic and photoplethysmographic examinations are non-invasive, painless, fast, and inexpensive. They are devoid of side effects, and there are no limitations in the frequency of their use and repetition. The usefulness of capillaroscopy and photoplethysmography in the study of microcirculation in diabetic patients indicates the vast application possibilities of these methods in clinical practice.