Details
- Autor(en) / Beteiligte
- Titel
- Preparation of Cross-linked Chitosan Quaternary Ammonium Salt Hydrogel Films Loading Drug of Gentamicin Sulfate for Antibacterial Wound Dressing
- Ist Teil von
- Marine drugs, 2021-08, Vol.19 (9), p.479
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Hydrogels, possessing high biocompatibility and adaptability to biological tissue, show great usability in medical applications. In this research, a series of novel cross-linked chitosan quaternary ammonium salt loading with gentamicin sulfate (CTMCSG) hydrogel films with different cross-linking degrees were successfully obtained by the reaction of chitosan quaternary ammonium salt (TMCS) and epichlorohydrin. Fourier transform infrared spectroscopy (FTIR), thermal analysis, and scanning electron microscope (SEM) were used to characterize the chemical structure and surface morphology of CTMCSG hydrogel films. The physicochemical property, gentamicin sulphate release behavior, cytotoxicity, and antibacterial activity of the CTMCSG against and were determined. Experimental results demonstrated that CTMCSG hydrogel films exhibited good water stability, thermal stability, drug release capacity, as well as antibacterial property. The inhibition zone of CTMCSG hydrogel films against and could be up to about 30 mm. Specifically, the increases in maximum decomposition temperature, mechanical property, water content, swelling degree, and a reduction in water vapor permeability of the hydrogel films were observed as the amount of the cross-linking agent increased. The results indicated that the CTMCSG-4 hydrogel film with an interesting physicochemical property, admirable antibacterial activity, and slight cytotoxicity showed the potential value as excellent antibacterial wound dressing.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1660-3397eISSN: 1660-3397DOI: 10.3390/md19090479Titel-ID: cdi_doaj_primary_oai_doaj_org_article_a381dc8a27634aadbd4b5898a265cfa0
- Format
- –
- Schlagworte
- Adaptability, Ammonium, Ammonium compounds, Ammonium salts, Analytical methods, Animals, Anti-Bacterial Agents - administration & dosage, Anti-Bacterial Agents - chemistry, Antibacterial activity, Antibiotics, Bandages, Biocompatibility, Biological activity, Cell Line, Cell Survival - drug effects, Chitosan, Chitosan - administration & dosage, Chitosan - chemistry, chitosan quaternary ammonium salt, Cross-Linking Reagents - chemistry, Crosslinking, Cytotoxicity, Decomposition, Delayed-Action Preparations - administration & dosage, Delayed-Action Preparations - chemistry, Drug Liberation, Drugs, E coli, Epichlorohydrin, Epichlorohydrin - chemistry, Escherichia coli, Escherichia coli - drug effects, Escherichia coli - growth & development, Fourier analysis, Fourier transforms, Gentamicin, Gentamicins - administration & dosage, Gentamicins - chemistry, hydrogel films, Hydrogels, Hydrogels - administration & dosage, Hydrogels - chemistry, Infections, Infrared analysis, Infrared spectroscopy, Mechanical properties, Medical research, Mice, Moisture content, Morphology, Permeability, Physicochemical processes, Quaternary, Quaternary Ammonium Compounds - administration & dosage, Quaternary Ammonium Compounds - chemistry, Quaternary ammonium salts, Salt loading, Scanning electron microscopy, Skin, Spectrum analysis, Staphylococcus aureus, Staphylococcus aureus - drug effects, Staphylococcus aureus - growth & development, Sulfates, Tensile Strength, Thermal analysis, Thermal stability, Tissues, Toxicity, Vibration, Water - chemistry, Water content, Water stability, Water vapor, Water vapour, Wound healing, Wound Healing - drug effects, Wounds