Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Construction of nano-assembly for mild photothermal therapy of tumors
Ist Teil von
BIO Web of Conferences, 2023, Vol.61, p.1002
Ort / Verlag
Les Ulis: EDP Sciences
Erscheinungsjahr
2023
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
Due to the high incidence and mortality rates of cancer, it is necessary to seek more targeted and effective treatment methods. Traditional cancer treatment methods have problems such as incomplete treatment and significant side effects. In recent years, photothermal therapy (PTT) has been considered one of the most promising treatment methods in the biomedical field. The treatment principle of PTT is to use materials with high photothermal conversion efficiency to absorb near-infrared light (NIR) and generate heat to ablate tumors. PTT has the advantages of low toxicity, non-invasiveness, strong specificity, and high controllability. However, the self-protective mechanism related to heat shock proteins (HSPs) gives cancer cells thermal tolerance. To minimize the thermal tolerance of cancer cells and improve the efficacy of PTT, a nano-assembly composed of Pluronic F-127 encapsulating the HSP inhibitor APO and the high photothermal conversion efficiency photosensitizer Cy7-TCF has been developed. The nano-assembly can accumulate at the tumor site and generate heat under near-infrared light irradiation. At the same time, it inhibits the expression of heat shock proteins, achieving the effect of mild photothermal therapy and reducing thermal damage to surrounding tissues.