Details

Autor(en) / Beteiligte

• Vaessen, Stefan F.C.
• Schaap, Frank G.
• Kuivenhoven, Jan-Albert
• Groen, Albert K.
• Hutten, Barbara A.
• Boekholdt, S. Matthijs
• Hattori, Hiroaki
• Sandhu, Manjinder S.
• Bingham, Sheila A.
• Luben, Robert
• Palmen, Jutta A.
• Wareham, Nicholas J.
• Humphries, Steve E.
• Kastelein, John J.P.
• Talmud, Philippa J.
• Khaw, Kay-Tee

Titel

Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study

Ist Teil von

• Journal of lipid research, 2006-09, Vol.47 (9), p.2064-2070

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2006

Link zum Volltext

Quelle

Electronic Journals Library - Freely accessible e-journals

Beschreibungen/Notizen

• In mouse models, apolipoprotein A-V (apoA-V) exhibits triglyceride (TG)-lowering effects. We investigated the apoA-V/TG relationship and the association of apoA-V with coronary artery disease (CAD) risk by determining serum apoA-V levels and genotypes in a nested case-control (n = 1,034/2,031) study. Both univariate and multivariate apoA-V levels showed no association with future CAD (P = 0.4 and 0.5, respectively). Unexpectedly, there was a significant positive correlation between serum apoA-V and TG in men and women (r = 0.36 and 0.28, respectively, P < 0.001 each) but a negative correlation between apoA-V and LPL mass (r = −0.14 and −0.12 for men and women respectively, P < 0.001 each). The frequency of the c.56C>G polymorphism did not differ between cases and controls despite significant positive association of c.56G with both apoA-V and TG levels. For −1131T>C, the minor allele was significantly associated with lower apoA-V yet higher TG levels and was overrepresented in cases (P = 0.047). The association of −1131T>C with CAD risk, however, was independent of apoA-V levels and likely acts through linkage disequilibrium with APOC3 variants. The positive correlation of apoA-V levels with TG levels, negative correlation with LPL levels, and lack of association with CAD risk highlight the need for further human studies to clarify the role of apoA-V.