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Autor(en) / Beteiligte

Titel

A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling

Ist Teil von

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from patients with acute lung injury from SARS-CoV-2 or other causes across 7 cohorts. This program was associated with greater clinical severity and predicted future mechanical ventilation and death. EN-RAGEhi myeloid cells express features consistent with suppressor cell functionality, including low HLA-DR and high PD-L1. Sustained EN-RAGE program expression in airway and blood myeloid cells correlated with clinical severity and increasing expression of T cell dysfunction markers. IL-6 upregulated many EN-RAGE program genes in monocytes in vitro. IL-6 signaling blockade by tocilizumab in a placebo-controlled clinical trial led to rapid normalization of EN-RAGE and T cell gene expression. This identifies IL-6 as a key driver of myeloid dysregulation associated with worse clinical outcomes in COVID-19 patients and provides insights into shared pathophysiological mechanisms in non-COVID-19 ARDS. [Display omitted] •The myeloid EN-RAGE program upregulated by IL-6 predicts ARDS mortality•EN-RAGEhi cells traffic to the airways in COVID-19 and non-COVID-19 ARDS•EN-RAGEhi cells express low HLA-DR and high PD-L1 that may impair T cell responses•IL-6R blockade in COVID-19 patients rapidly normalizes EN-RAGE expression and T cells Clinical genetics; Molecular medicine; Immune response

Sprache: Englisch
Identifikatoren: ISSN: 2589-0042
eISSN: 2589-0042
DOI: 10.1016/j.isci.2023.107813
Titel-ID: cdi_doaj_primary_oai_doaj_org_article_9fcf76e7c2d9439cbd17b0a0b7fa8d89

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