Details

Autor(en) / Beteiligte

• Lin, Tzu-Lung
• Lu, Chia-Chen
• Lai, Wei-Fan
• Wu, Ting-Shu
• Lu, Jang-Jih
• Chen, Young-Mao
• Tzeng, Chi-Meng
• Liu, Hong-Tao
• Wei, Hong
• Lai, Hsin-Chih

Titel

Role of gut microbiota in identification of novel TCM-derived active metabolites

Ist Teil von

• Protein & cell, 2021-05, Vol.12 (5), p.394-410

Ort / Verlag

Beijing: Higher Education Press

Erscheinungsjahr

2021

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Traditional Chinese Medicine (TCM) has been extensively used to ameliorate diseases in Asia for over thousands of years. However, owing to a lack of formal scientific validation, the absence of information regarding the mechanisms underlying TCMs restricts their application. After oral administration, TCM herbal ingredients frequently are not directly absorbed by the host, but rather enter the intestine to be transformed by gut microbiota. The gut microbiota is a microbial community living in animal intestines, and functions to maintain host homeostasis and health. Increasing evidences indicate that TCM herbs closely affect gut microbiota composition, which is associated with the conversion of herbal components into active metabolites. These may significantly affect the therapeutic activity of TCMs. Microbiota analyses, in conjunction with modern multiomics platforms, can together identify novel functional metabolites and form the basis of future TCM research.