Details

Autor(en) / Beteiligte

• Ecklu-Mensah, Gertrude
• Choo-Kang, Candice
• Maseng, Maria Gjerstad
• Donato, Sonya
• Bovet, Pascal
• Viswanathan, Bharathi
• Bedu-Addo, Kweku
• Plange-Rhule, Jacob
• Oti Boateng, Prince
• Forrester, Terrence E.
• Williams, Marie
• Lambert, Estelle V.
• Rae, Dale
• Sinyanya, Nandipha
• Luke, Amy
• Layden, Brian T.
• O’Keefe, Stephen
• Gilbert, Jack A.
• Dugas, Lara R.

Titel

Gut microbiota and fecal short chain fatty acids differ with adiposity and country of origin: the METS-microbiome study

Ist Teil von

• Nature communications, 2023-08, Vol.14 (1), p.5160-17, Article 5160

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• The relationship between microbiota, short chain fatty acids (SCFAs), and obesity remains enigmatic. We employ amplicon sequencing and targeted metabolomics in a large ( n  = 1904) African origin cohort from Ghana, South Africa, Jamaica, Seychelles, and the US. Microbiota diversity and fecal SCFAs are greatest in Ghanaians, and lowest in Americans, representing each end of the urbanization spectrum. Obesity is significantly associated with a reduction in SCFA concentration, microbial diversity, and SCFA synthesizing bacteria, with country of origin being the strongest explanatory factor. Diabetes, glucose state, hypertension, obesity, and sex can be accurately predicted from the global microbiota, but when analyzed at the level of country, predictive accuracy is only universally maintained for sex. Diabetes, glucose, and hypertension are only predictive in certain low-income countries. Our findings suggest that adiposity-related microbiota differences differ between low-to-middle-income compared to high-income countries. Further investigation is needed to determine the factors driving this association. Here, using amplicon sequencing and metabolomics in a large multi-country cohort, the authors find that adiposity-related microbiota differences differ between low-to-middle-income compared to high-income countries.