Details

Autor(en) / Beteiligte

• Leung, Kenneth Siu-Sing
• Ng, Timothy Ting-Leung
• Wu, Alan Ka-Lun
• Yau, Miranda Chong-Yee
• Lao, Hiu-Yin
• Choi, Ming-Pan
• Tam, Kingsley King-Gee
• Lee, Lam-Kwong
• Wong, Barry Kin-Chung
• Man Ho, Alex Yat
• Yip, Kam-Tong
• Lung, Kwok-Cheung
• Liu, Raymond Wai-To
• Tso, Eugene Yuk-Keung
• Leung, Wai-Shing
• Chan, Man-Chun
• Ng, Yuk-Yung
• Sin, Kit-Man
• Fung, Kitty Sau-Chun
• Chau, Sandy Ka-Yee
• To, Wing-Kin
• Que, Tak-Lun
• Shum, David Ho-Keung
• Yip, Shea Ping
• Yam, Wing Cheong
• Siu, Gilman Kit-Hang

Titel

Territorywide Study of Early Coronavirus Disease Outbreak, Hong Kong, China

Ist Teil von

• Emerging infectious diseases, 2021-01, Vol.27 (1), p.196-204

Ort / Verlag

United States: U.S. National Center for Infectious Diseases

Erscheinungsjahr

2021

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Initial cases of coronavirus disease in Hong Kong were imported from mainland China. A dramatic increase in case numbers was seen in February 2020. Most case-patients had no recent travel history, suggesting the presence of transmission chains in the local community. We collected demographic, clinical, and epidemiologic data from 50 patients, who accounted for 53.8% of total reported case-patients as of February 28, 2020. We performed whole-genome sequencing to determine phylogenetic relationship and transmission dynamics of severe acute respiratory syndrome coronavirus 2 infections. By using phylogenetic analysis, we attributed the community outbreak to 2 lineages; 1 harbored a common mutation, Orf3a-G251V, and accounted for 88.0% of the cases in our study. The estimated time to the most recent common ancestor of local coronavirus disease outbreak was December 24, 2019, with an evolutionary rate of 3.04 × 10 substitutions/site/year. The reproduction number was 1.84, indicating ongoing community spread.