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Ground-based telescopes are often affected by vignetting, stray light and detector nonuniformity when acquiring space images. This paper presents a space image nonuniform correction method using the conditional generative adversarial network (
). Firstly, we create a dataset for training by introducing the physical vignetting model and by designing the simulation polynomial to realize the nonuniform background. Secondly, we develop a robust conditional generative adversarial network (
) for learning the nonuniform background, in which we improve the network structure of the generator. The experimental results include a simulated dataset and authentic space images. The proposed method can effectively remove the nonuniform background of space images, achieve the Mean Square Error (
) of 4.56 in the simulation dataset, and improve the target's signal-to-noise ratio (
) by 43.87% in the real image correction.