Details

Autor(en) / Beteiligte

• Viedma, Esther
• Juan, Carlos
• Villa, Jennifer
• Barrado, Laura
• Orellana, M Angeles
• Sanz, Francisca
• Otero, Joaquín R
• Oliver, Antonio
• Chaves, Fernando

Titel

VIM-2-producing multidrug-resistant Pseudomonas aeruginosa ST175 clone, Spain

Ist Teil von

• Emerging infectious diseases, 2012-08, Vol.18 (8), p.1235-1241

Ort / Verlag

United States: U.S. National Center for Infectious Diseases

Erscheinungsjahr

2012

Quelle

Open access e-journals list

Beschreibungen/Notizen

• A total of 183 patients were colonized or infected with multidrug-resistant Pseudomonas aeruginosa isolates at a hospital in Spain during 2007-2010; prevalence increased over this period from 2.8% to 15.3%. To characterize these isolates, we performed molecular epidemiologic and drug resistance analysis. Genotyping showed that 104 (56.8%) isolates belonged to a single major clone (clone B), which was identified by multilocus sequence typing as sequence type (ST) 175. This clone was initially isolated from 5 patients in 2008, and then isolated from 23 patients in 2009 and 76 patients in 2010. PCR analysis of clone B isolates identified the bla(VIM-2) gene in all but 1 isolate, which harbored bla(IMP-22). ST175 isolates were susceptible to only amikacin (75%) and colistin (100%). Emergence of the ST175 clone represents a major health problem because it compromises therapy for treatment of P. aeruginosa nosocomial infections.