Stem cells international, 2018-01, Vol.2018, p.5416923-16
2018
Details
- Autor(en) / Beteiligte
- Titel
- Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment
- Ist Teil von
- Stem cells international, 2018-01, Vol.2018, p.5416923-16
- Ort / Verlag
- United States: Hindawi
- Erscheinungsjahr
- 2018
- Link zum Volltext
- Quelle
- EZB Free E-Journals
- Beschreibungen/Notizen
- Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), are suggested to be responsible for drug resistance and cancer relapse due in part to their ability to self-renew themselves and differentiate into heterogeneous lineages of cancer cells. Thus, it is important to understand the characteristics and mechanisms by which CSCs display resistance to therapeutic agents. In this review, we highlight the key features and mechanisms that regulate CSC function in drug resistance as well as recent breakthroughs of therapeutic approaches for targeting CSCs. This promises new insights of CSCs in drug resistance and provides better therapeutic rationales to accompany novel anticancer therapeutics.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1687-966X, 1687-9678eISSN: 1687-9678DOI: 10.1155/2018/5416923Titel-ID: cdi_doaj_primary_oai_doaj_org_article_9d96ab90b6974448a2cad734282e0083
- Format
- –
- Schlagworte
- Bevacizumab, Brain cancer, Brain research, Breast cancer, Cancer, Cancer cells, Cancer recurrence, Cancer therapies, Cell cycle, Cetuximab, Chemical compounds, Chemotherapy, Development and progression, Displays (Marketing), Drug resistance, Health aspects, Identification, Medical research, Pharmacology, Radiation therapy, Recurrence (Disease), Review, Stem cells, Stomach cancer, Surgery, Therapeutics, Tumors