Details

Autor(en) / Beteiligte

• Sun, Yuxuan
• Zhang, Wang
• Gu, Junnan
• Xia, Liangyu
• Cao, Yinghao
• Zhu, Xinhui
• Wen, Hao
• Ouyang, Shaowei
• Liu, Ruiqi
• Li, Jialong
• Jiang, Zhenxing
• Cheng, Denglong
• Lv, Yiliang
• Han, Xiaotao
• Qiu, Wu
• Cai, Kailin
• Song, Enmin
• Cao, Quanliang
• Li, Liang

Titel

Magnetically driven capsules with multimodal response and multifunctionality for biomedical applications

Ist Teil von

• Nature communications, 2024-02, Vol.15 (1), p.1839-1839, Article 1839

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Untethered capsules hold clinical potential for the diagnosis and treatment of gastrointestinal diseases. Although considerable progress has been achieved recently in this field, the constraints imposed by the narrow spatial structure of the capsule and complex gastrointestinal tract environment cause many open-ended problems, such as poor active motion and limited medical functions. In this work, we describe the development of small-scale magnetically driven capsules with a distinct magnetic soft valve made of dual-layer ferromagnetic soft composite films. A core technological advancement achieved is the flexible opening and closing of the magnetic soft valve by using the competitive interactions between magnetic gradient force and magnetic torque, laying the foundation for the functional integration of both drug release and sampling. Meanwhile, we propose a magnetic actuation strategy based on multi-frequency response control and demonstrate that it can achieve effective decoupled regulation of the capsule’s global motion and local responses. Finally, through a comprehensive approach encompassing ideal models, animal ex vivo models, and in vivo assessment, we demonstrate the versatility of the developed magnetic capsules and their multiple potential applications in the biomedical field, such as targeted drug delivery and sampling, selective dual-drug release, and light/thermal-assisted therapy. Untethered capsules exhibit clinical promise for diagnosing and treating gastrointestinal diseases. Here, the authors develop small-scale magnetically driven capsules featuring a distinct magnetic soft valve, integrating multiple functional and motion modalities for biomedical applications.