Details

Autor(en) / Beteiligte

• Romero-Ibarguengoitia, Maria Elena
• Flores-Salazar, Zulema Lourdes
• Arroyo-García, Kimberly Dariela
• Soto-Gámez, Rafael
• Leal-Meléndez, Jessica Andrea
• René Garza-Herrera, Mauricio
• Bennett-Vidales, Gordon
• Cabrera, Mauricio Hurtado
• González-Habib, Roberto
• Jiménez, Liliann Peña
• Garza-Bulnes, Raúl
• Barco-Flores, Irene Antonieta
• Castillo-Figueroa, Luis Fernando
• Garza-Silva, Arnulfo
• Rivera-Cavazos, Andrea
• Rivera-Salinas, Diego
• González-Cantú, Arnulfo
• Sanz-Sánchez, Miguel Ángel

Titel

Evaluation of Transplacental Antibody Transfer in Pregnant Women Immunized with Different SARS-CoV-2 Homologous or Heterologous Schemes

Ist Teil von

• Vaccines (Basel), 2023-02, Vol.11 (2), p.415

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2023

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• There is scarce information related to transplacental antibody transfer against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with different homologous and heterologous vaccination schemes. This study aimed to correlate the magnitude of transplacental transfer anti-SARS-CoV-2 antibodies in different homologous and heterologous schemes. An observational cross-sectional study was developed to identify pregnant women vaccinated against SARS-CoV-2. They were questioned about their immunization status; blood samples from the mother, umbilical cord during labor, and the newborn 72 h after birth were taken to measure anti-S1 and anti-S2 specific IgG antibodies for SARS-CoV-2. We recruited 104 women with a median age of 29 (SD 1.17). We found antibodies in all newborns with vaccinated mothers. Homologous BNT162b2 mRNA regimen had the highest mean (SD) antibody titers (AU/mL) in maternal (994.93 (3.08), = 0.039), umbilical cord (1316.43 (2.79), = 0.016), and newborn (1192.02 (3.55), = 0.020) blood. The generalized linear model showed a positive effect over antibodies with at least one dose in maternal (β = -1.1, = 0.002) and newborn (β= -0.717, = 0.044) blood, and with two doses (β = -0.684, = 0.026) in umbilical cord blood. In conclusion, antibodies were detected in all vaccinated women and their newborns. Transfer of antibodies was found from the first dose, and the levels increased with the number of vaccine doses. Vaccination should be encouraged in pregnant women with any available scheme.