Details

Autor(en) / Beteiligte

• Pirr, Sabine
• Dauter, Louise
• Vogl, Thomas
• Ulas, Thomas
• Bohnhorst, Bettina
• Roth, Johannes
• Viemann, Dorothee

Titel

S100A8/A9 is the first predictive marker for neonatal sepsis

Ist Teil von

• Clinical and translational medicine, 2021-04, Vol.11 (4), p.e338-n/a

Ort / Verlag

United States: John Wiley & Sons, Inc

Erscheinungsjahr

2021

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Dear Editor, Neonatal sepsis is a leading cause of childhood mortality worldwide particularly affecting preterm infants, who are often exposed to empirical antibiotics since sepsis biomarkers lack sensitivity in this patient group and markers predicting the risk of sepsis have not been identified yet.1,2 In our study, serum S100A8/A9 proved as an independent predictive marker of late-onset neonatal sepsis (LOS) in preterm infants, which for the first time offers the opportunity to change current treatment policies by improving antibiotic stewardship and timely individualized therapeutic intervention. [...]serum S100A8/A9 did not outcompete sepsis marker like CRP and IL-6 (Figure 1B–D) currently used in the clinical routine. SEE PDF] Next, we investigated the influence of the following common sepsis risk factors on S100A8/A9 serum levels during the first 2 days of life in a cohort of 198 at birth healthy preterm infants (Table S2 and Methods in the Supporting Information): delivery by cesarean section (CS), birth weight (BW) of <1000 g, BW small for gestational age (SGA) (below the 10th percentile), male sex, insertion of a central venous line (CVL), and the need of invasive mechanical ventilation (IMV)8,9 as detailed in the Supporting Information.