Details

Autor(en) / Beteiligte

• Cheng, Ming-Ya
• Hsu, I-Chi
• Huang, Shi-Ying
• Chuang, Ya-Ting
• Ke, Tzi-Yi
• Chang, Hsueh-Wei
• Chu, Tian-Huei
• Chen, Ching-Yeu
• Cheng, Yuan-Bin

Titel

Marine Prostanoids with Cytotoxic Activity from Octocoral Clavularia spp

Ist Teil von

• Marine drugs, 2024-05, Vol.22 (5), p.219

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2024

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Octocoral of the genus is a kind of marine invertebrate possessing abundant cytotoxic secondary metabolites, such as prostanoids and dolabellanes. In our continuous natural product study of spp., two previously undescribed prostanoids [clavulone I-15-one ( ) and 12- -deacetylclavulone I ( )] and eleven known analogs ( - ) were identified. The structures of these new compounds were elucidated based on analysis of their 1D and 2D NMR, HRESIMS, and IR data. Additionally, all tested prostanoids ( and - ) showed potent cytotoxic activities against the human oral cancer cell line (Ca9-22). The major compound showed cytotoxic activity against the Ca9-22 cells with the IC value of 2.11 ± 0.03 μg/mL, which echoes the cytotoxic effect of the coral extract. In addition, in silico tools were used to predict the possible effects of isolated compounds on human tumor cell lines and nitric oxide production, as well as the pharmacological potentials.