Details

Autor(en) / Beteiligte

• Shuvalova, L.D.
• Eremeev, A.V.
• Bogomazova, A.N.
• Novosadova, E.V.
• Zerkalenkova, E.A.
• Olshanskaya, Yu.V.
• Fedotova, E.Y.
• Glagoleva, E.S.
• Illarioshkin, S.N.
• Lebedeva, O.S.
• Lagarkova, M.A.

Titel

Generation of induced pluripotent stem cell line RCPCMi004-A derived from patient with Parkinson's disease with deletion of the exon 2 in PARK2 gene

Ist Teil von

• Stem cell research, 2020-04, Vol.44, p.101733-101733, Article 101733

Ort / Verlag

England: Elsevier B.V

Erscheinungsjahr

2020

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• IPSC line RCPCMi004-A was generated from skin fibroblasts collected from a male patient with early onset Parkinson's disease. The patient carries a heterozygous deletion of the exon 2 of PARK2 gene. The reprogramming of fibroblasts was performed with Sendai viruses containing Oct-4, Sox-2, Klf-4 and c-Myc. Pluripotency was confirmed by immunofluorescence, RT-PCR, and formation of embryoid bodies. The RCPCMi004-A cell line carries the same deletion in PARK2 gene. The RCPCMi004-A cell line can be used to model Parkinson's disease in vitro.