Biomolecules (Basel, Switzerland), 2022-12, Vol.12 (12), p.1830
2022
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Details
- Autor(en) / Beteiligte
- Titel
- Weil's Disease-Immunopathogenesis, Multiple Organ Failure, and Potential Role of Gut Microbiota
- Ist Teil von
- Biomolecules (Basel, Switzerland), 2022-12, Vol.12 (12), p.1830
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2022
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Leptospirosis is an important zoonotic disease, causing about 60,000 deaths annually. In this review, we have described in detail the immunopathogenesis of leptospirosis, the influence of cytokines, genetic susceptibility on the course of the disease, and the evasion of the immune response. These data are combined with information about immunological and pathomorphological changes in the kidneys, liver, and lungs, which are most affected by Weil's disease. The review also suggests a possible role of the gut microbiota in the clinical course of leptospirosis, the main mechanisms of the influence of gut dysbiosis on damage in the liver, kidneys, and lungs through several axes, i.e., gut-liver, gut-kidney, and gut-lungs. Modulation of gut microbiota by probiotics and/or fecal microbiota transplantation in leptospirosis may become an important area of scientific research.
- Sprache
- Englisch; Norwegisch
- Identifikatoren
- ISSN: 2218-273XeISSN: 2218-273XDOI: 10.3390/biom12121830Titel-ID: cdi_doaj_primary_oai_doaj_org_article_99fb86d746db45b897c1c7edc7e527da
- Format
- –
- Schlagworte
- Antigens, Causes of, Chemokines, Cytokine storm, Cytokines, Disease, Disease susceptibility, Dysbacteriosis, dysbiosis, Fecal microflora, Gastrointestinal Microbiome, Genes, Genetic aspects, Health aspects, Humans, Immune response, Immune system, Immunopathogenesis, Infections, Inflammation, Intestinal microflora, Kidneys, Leptospirosis, Liver, Liver - pathology, Microbiota, Microbiota (Symbiotic organisms), Mortality, Multiple Organ Failure - pathology, Neutrophils, Pathogenesis, Pathogens, Physiological aspects, Probiotics, Review, Transplantation, Tumor necrosis factor-TNF, Weil Disease - pathology, Weil’s disease, Zoonoses