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MoCbp7, a Novel Calcineurin B Subunit-Binding Protein, Is Involved in the Calcium Signaling Pathway and Regulates Fungal Development, Virulence, and ER Homeostasis in Magnaporthe oryzae
Ist Teil von
International journal of molecular sciences, 2023-05, Vol.24 (11), p.9297
Ort / Verlag
Switzerland: MDPI AG
Erscheinungsjahr
2023
Quelle
EZB Free E-Journals
Beschreibungen/Notizen
Calcineurin, a key regulator of the calcium signaling pathway, is involved in calcium signal transduction and calcium ion homeostasis.
is a devastating filamentous phytopathogenic fungus in rice, yet little is known about the function of the calcium signaling system. Here, we identified a novel calcineurin regulatory-subunit-binding protein, MoCbp7, which is highly conserved in filamentous fungi and was found to localize in the cytoplasm. Phenotypic analysis of the
gene deletion mutant (Δ
) showed that MoCbp7 influenced the growth, conidiation, appressorium formation, invasive growth, and virulence of
. Some calcium-signaling-related genes, such as
,
, and
, are expressed in a calcineurin/MoCbp7-dependent manner. Furthermore, MoCbp7 synergizes with calcineurin to regulate endoplasmic reticulum homeostasis. Our research indicated that
may have evolved a new calcium signaling regulatory network to adapt to its environment compared to the fungal model organism
.