Details

Autor(en) / Beteiligte

• Wang, Zi-He
• Shen, Zi-Fang
• Wang, Jing-Yi
• Cai, Ying-Ying
• Li, Lin
• Liao, Jian
• Lu, Jian-Ping
• Zhu, Xue-Ming
• Lin, Fu-Cheng
• Liu, Xiao-Hong

Titel

MoCbp7, a Novel Calcineurin B Subunit-Binding Protein, Is Involved in the Calcium Signaling Pathway and Regulates Fungal Development, Virulence, and ER Homeostasis in Magnaporthe oryzae

Ist Teil von

• International journal of molecular sciences, 2023-05, Vol.24 (11), p.9297

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2023

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Calcineurin, a key regulator of the calcium signaling pathway, is involved in calcium signal transduction and calcium ion homeostasis. is a devastating filamentous phytopathogenic fungus in rice, yet little is known about the function of the calcium signaling system. Here, we identified a novel calcineurin regulatory-subunit-binding protein, MoCbp7, which is highly conserved in filamentous fungi and was found to localize in the cytoplasm. Phenotypic analysis of the gene deletion mutant (Δ ) showed that MoCbp7 influenced the growth, conidiation, appressorium formation, invasive growth, and virulence of . Some calcium-signaling-related genes, such as , , and , are expressed in a calcineurin/MoCbp7-dependent manner. Furthermore, MoCbp7 synergizes with calcineurin to regulate endoplasmic reticulum homeostasis. Our research indicated that may have evolved a new calcium signaling regulatory network to adapt to its environment compared to the fungal model organism .