Details

Autor(en) / Beteiligte

• Ling, Lloyd
• Aldoghachi, Ahmed Faris
• Chong, Zhi Xiong
• Ho, Wan Yong
• Yeap, Swee Keong
• Chin, Ren Jie
• Soo, Eugene Zhen Xiang
• Khor, Jen Feng
• Yong, Yoke Leng
• Ling, Joan Lucille
• Yan, Naing Soe
• Ong, Alan Han Kiat

Titel

Addressing the Clinical Feasibility of Adopting Circulating miRNA for Breast Cancer Detection, Monitoring and Management with Artificial Intelligence and Machine Learning Platforms

Ist Teil von

• International journal of molecular sciences, 2022-12, Vol.23 (23), p.15382

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2022

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Detecting breast cancer (BC) at the initial stages of progression has always been regarded as a lifesaving intervention. With modern technology, extensive studies have unraveled the complexity of BC, but the current standard practice of early breast cancer screening and clinical management of cancer progression is still heavily dependent on tissue biopsies, which are invasive and limited in capturing definitive cancer signatures for more comprehensive applications to improve outcomes in BC care and treatments. In recent years, reviews and studies have shown that liquid biopsies in the form of blood, containing free circulating and exosomal microRNAs (miRNAs), have become increasingly evident as a potential minimally invasive alternative to tissue biopsy or as a complement to biomarkers in assessing and classifying BC. As such, in this review, the potential of miRNAs as the key BC signatures in liquid biopsy are addressed, including the role of artificial intelligence (AI) and machine learning platforms (ML), in capitalizing on the big data of miRNA for a more comprehensive assessment of the cancer, leading to practical clinical utility in BC management.