Details

Autor(en) / Beteiligte

• Zegarra-Valdivia, Jonathan A.
• Chaves-Coira, Irene
• Fernandez de Sevilla, Maria Estrella
• Martinez-Rachadell, Laura
• Esparza, Julio
• Torres-Aleman, Ignacio
• Nuñez, Angel

Titel

Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse

Ist Teil von

• Frontiers in aging neuroscience, 2021-09, Vol.13, p.682388-682388

Ort / Verlag

Lausanne: Frontiers Research Foundation

Erscheinungsjahr

2021

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• It is known that aging is frequently accompanied by a decline in cognition. Furthermore, aging is associated with lower serum IGF-I levels that may contribute to this deterioration. We studied the effect of IGF-I in neurons of the horizontal diagonal band of Broca (HDB) of young (≤6 months old) and old (≥20-month-old) mice to determine if changes in the response of these neurons to IGF-I occur along with aging. Local injection of IGF-I in the HDB nucleus increased their neuronal activity and induced fast oscillatory activity in the electrocorticogram (ECoG). Furthermore, IGF-I facilitated tactile responses in the primary somatosensory cortex elicited by air-puffs delivered in the whiskers. These excitatory effects decreased in old mice. Immunohistochemistry showed that cholinergic HDB neurons express IGF-I receptors and that IGF-I injection increased the expression of c-fos in young, but not in old animals. IGF-I increased the activity of optogenetically-identified cholinergic neurons in young animals, suggesting that most of the IGF-I-induced excitatory effects were mediated by activation of these neurons. Effects of aging were partially ameliorated by chronic IGF-I treatment in old mice. The present findings suggest that reduced IGF-I activity in old animals participates in age-associated changes in cortical activity.