Details

Autor(en) / Beteiligte

• França, Camila Tenorio
• White, Michael T
• He, Wen-Qiang
• Hostetler, Jessica B
• Brewster, Jessica
• Frato, Gabriel
• Malhotra, Indu
• Gruszczyk, Jakub
• Huon, Christele
• Lin, Enmoore
• Kiniboro, Benson
• Yadava, Anjali
• Siba, Peter
• Galinski, Mary R
• Healer, Julie
• Chitnis, Chetan
• Cowman, Alan F
• Takashima, Eizo
• Tsuboi, Takafumi
• Tham, Wai-Hong
• Fairhurst, Rick M
• Rayner, Julian C
• King, Christopher L
• Mueller, Ivo

Titel

Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development

Ist Teil von

• eLife, 2017-09, Vol.6

Ort / Verlag

England: eLife Sciences Publications Ltd

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• The study of antigenic targets of naturally-acquired immunity is essential to identify and prioritize antigens for further functional characterization. We measured total IgG antibodies to 38 antigens, investigating their relationship with prospective risk of malaria in a cohort of 1-3 years old Papua New Guinean children. Using simulated annealing algorithms, the potential protective efficacy of antibodies to multiple antigen-combinations, and the antibody thresholds associated with protection were investigated for the first time. High antibody levels to multiple known and newly identified proteins were strongly associated with protection (IRR 0.44-0.74, p<0.001-0.041). Among five-antigen combinations with the strongest protective effect (>90%), EBP, DBPII, RBP1a, CyRPA, and PVX_081550 were most frequently identified; several of them requiring very low antibody levels to show a protective association. These data identify individual antigens that should be prioritized for further functional testing and establish a clear path to testing a multicomponent vaccine.