Details

Autor(en) / Beteiligte

• Al Abed, Alice Shaam
• Ducourneau, Eva-Gunnel
• Bouarab, Chloé
• Sellami, Azza
• Marighetto, Aline
• Desmedt, Aline

Titel

Preventing and treating PTSD-like memory by trauma contextualization

Ist Teil von

• Nature communications, 2020-08, Vol.11 (1), p.4220-4220, Article 4220

Ort / Verlag

London: Nature Publishing Group

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Abstract Post-traumatic stress disorder (PTSD) is characterized by emotional hypermnesia on which preclinical studies focus so far. While this hypermnesia relates to salient traumatic cues, partial amnesia for the traumatic context can also be observed. Here, we show in mice that contextual amnesia is causally involved in PTSD-like memory formation, and that treating the amnesia by re-exposure to all trauma-related cues cures PTSD-like hypermnesia. These findings open a therapeutic perspective based on trauma contextualization and the underlying hippocampal mechanisms.