Marine drugs, 2013-11, Vol.11 (11), p.4419-4434
2013
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Details
- Autor(en) / Beteiligte
- Titel
- Crambescidin-816 acts as a fungicidal with more potency than crambescidin-800 and -830, inducing cell cycle arrest, increased cell size and apoptosis in Saccharomyces cerevisiae
- Ist Teil von
- Marine drugs, 2013-11, Vol.11 (11), p.4419-4434
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- In this paper, we show the effect of crambescidin-816, -800, and -830 on Saccharomyces cerevisiae viability. We determined that, of the three molecules tested, crambescidin-816 was the most potent. Based on this result, we continued by determining the effect of crambescidin-816 on the cell cycle of this yeast. The compound induced cell cycle arrest in G2/M followed by an increase in cell DNA content and size. When the type of cell death was analyzed, we observed that crambescidin-816 induced apoptosis. The antifungal effect indicates that crambescidins, and mostly crambescidin-816, could serve as a lead compound to fight fungal infections.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1660-3397eISSN: 1660-3397DOI: 10.3390/md11114419Titel-ID: cdi_doaj_primary_oai_doaj_org_article_97c7a57f7b14451d92f4a68d048da04e
- Format
- –
- Schlagworte
- Alkaloids - pharmacology, antifungal, apoptosis, Apoptosis - drug effects, cell cycle arrest, Cell Cycle Checkpoints - drug effects, Cell Death - drug effects, Cell Division - drug effects, Cell Size - drug effects, crambescidine-816, Fungicides, Industrial - pharmacology, G2 Phase - drug effects, Guanidine - analogs & derivatives, Guanidine - pharmacology, Membrane Potential, Mitochondrial - drug effects, Saccharomyces cerevisiae - drug effects, Spiro Compounds - pharmacology