Nature communications, 2017-01, Vol.8 (1), p.13815-13815, Article 13815
2017
Details
- Autor(en) / Beteiligte
- Titel
- JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling
- Ist Teil von
- Nature communications, 2017-01, Vol.8 (1), p.13815-13815, Article 13815
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2017
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- A stable pool of morphogen-producing cells is critical for the development of any organ or tissue. Here we present evidence that JAK/STAT signalling in the Drosophila wing promotes the cycling and survival of Hedgehog-producing cells, thereby allowing the stable localization of the nearby BMP/Dpp-organizing centre in the developing wing appendage. We identify the inhibitor of apoptosis dIAP1 and Cyclin A as two critical genes regulated by JAK/STAT and contributing to the growth of the Hedgehog-expressing cell population. We also unravel an early role of JAK/STAT in guaranteeing Wingless-mediated appendage specification, and a later one in restricting the Dpp-organizing activity to the appendage itself. These results unveil a fundamental role of the conserved JAK/STAT pathway in limb specification and growth by regulating morphogen production and signalling, and a function of pro-survival cues and mitogenic signals in the regulation of the pool of morphogen-producing cells in a developing organ.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/ncomms13815Titel-ID: cdi_doaj_primary_oai_doaj_org_article_977a2cedc31b45d0909673b32b8e5572
- Format
- –
- Schlagworte
- Animals, Bone Morphogenetic Protein Receptors - genetics, Bone Morphogenetic Protein Receptors - metabolism, Cyclin A - genetics, Cyclin A - metabolism, Drosophila, Drosophila melanogaster - genetics, Drosophila melanogaster - growth & development, Drosophila melanogaster - metabolism, Drosophila Proteins - genetics, Drosophila Proteins - metabolism, Drosòfila, Gene Expression Regulation, Developmental, Hedgehog Proteins - genetics, Hedgehog Proteins - metabolism, Inhibitor of Apoptosis Proteins - genetics, Inhibitor of Apoptosis Proteins - metabolism, Insects, Janus Kinases - genetics, Janus Kinases - metabolism, Kinases, Morfogènesi, Morphogenesis, Morphogenesis - genetics, Organ Size, Signal Transduction, STAT Transcription Factors - genetics, STAT Transcription Factors - metabolism, Transcription Factors - genetics, Transcription Factors - metabolism, Wings, Animal - cytology, Wings, Animal - growth & development, Wings, Animal - metabolism, Wnt1 Protein - genetics, Wnt1 Protein - metabolism