Details

Autor(en) / Beteiligte

• Iampietro, Mathieu
• Dumont, Claire
• Mathieu, Cyrille
• Spanier, Julia
• Robert, Jonathan
• Charpenay, Aude
• Dupichaud, Sébastien
• Dhondt, Kévin P.
• Aurine, Noémie
• Pelissier, Rodolphe
• Ferren, Marion
• Mély, Stéphane
• Gerlier, Denis
• Kalinke, Ulrich
• Horvat, Branka

Titel

Activation of cGAS/STING pathway upon paramyxovirus infection

Ist Teil von

• iScience, 2021-06, Vol.24 (6), p.102519-102519, Article 102519

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• During inflammatory diseases, cancer, and infection, the cGAS/STING pathway is known to recognize foreign or self-DNA in the cytosol and activate an innate immune response. Here, we report that negative-strand RNA paramyxoviruses, Nipah virus (NiV), and measles virus (MeV), can also trigger the cGAS/STING axis. Although mice deficient for MyD88, TRIF, and MAVS still moderately control NiV infection when compared with wild-type mice, additional STING deficiency resulted in 100% lethality, suggesting synergistic roles of these pathways in host protection. Moreover, deletion of cGAS or STING resulted in decreased type I interferon production with enhanced paramyxoviral infection in both human and murine cells. Finally, the phosphorylation and ubiquitination of STING, observed during viral infections, confirmed the activation of cGAS/STING pathway by NiV and MeV. Our data suggest that cGAS/STING activation is critical in controlling paramyxovirus infection and possibly represents attractive targets to develop countermeasures against severe disease induced by these pathogens. [Display omitted] •RNA sensors are insufficient for the effective control of paramyxovirus infection•STING adaptor protein is involved in controlling Nipah virus infection in mice•cGAS/STING axis is primordial for optimal production of IFN-I against NiV and MeV•STING protein can be activated during infections by RNA viruses Immune system; Molecular biology; Virology