Details

Autor(en) / Beteiligte

• Westphal, Sabine
• Stoppe, Christian
• Gruenewald, Matthias
• Bein, Berthold
• Renner, Jochen
• Cremer, Jochen
• Coburn, Mark
• Schaelte, Gereon
• Boening, Andreas
• Niemann, Bernd
• Kletzin, Frank
• Roesner, Jan
• Strouhal, Ulrich
• Reyher, Christian
• Laufenberg-Feldmann, Rita
• Ferner, Marion
• Brandes, Ivo F
• Bauer, Martin
• Kortgen, Andreas
• Stehr, Sebastian N
• Wittmann, Maria
• Baumgarten, Georg
• Struck, Rafael
• Meyer-Treschan, Tanja
• Kienbaum, Peter
• Heringlake, Matthias
• Schoen, Julika
• Sander, Michael
• Treskatsch, Sascha
• Smul, Thorsten
• Wolwender, Ewa
• Schilling, Thomas
• Degenhardt, Frauke
• Franke, Andre
• Mucha, Soeren
• Tittmann, Lukas
• Kohlhaas, Madeline
• Fuernau, Georg
• Brosteanu, Oana
• Hasenclever, Dirk
• Zacharowski, Kai
• Meybohm, Patrick

Titel

Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study

Ist Teil von

• BMC cardiovascular disorders, 2019-01, Vol.19 (1), p.26-26, Article 26

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2019

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery. We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery. A total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance (PHLPP2, rs78064607, p = 3.77 × 10 ) and 139 (adjusted for all other outcomes) SNPs showed promising association with p < 1 × 10 from the GWAS. We identified several potential loci, in particular PHLPP2, BBS9, RyR2, DUSP4 and HSPA8, associated with new-onset of atrial fibrillation, delirium, myocardial infarction, acute kidney injury and stroke after cardiac surgery. The study was registered with ClinicalTrials.gov NCT01067703, prospectively registered on 11 Feb 2010.