Details

Autor(en) / Beteiligte

• Osseis, Michael
• Esposito, Francesco
• Lim, Chetana
• Doussot, Alexandre
• Lahat, Eylon
• Fuentes, Liliana
• Moussallem, Toufic
• Salloum, Chady
• Azoulay, Daniel

Titel

Impact of postoperative complications on long-term survival following surgery for T4 colorectal cancer

Ist Teil von

• BMC surgery, 2018-10, Vol.18 (1), p.87-87, Article 87

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2018

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Postoperative complications (POCs) after the resection of locally advanced colorectal cancer (CRC) may influence adjuvant treatment timing, outcomes, and survival. This study aimed to evaluate the impact of POCs on long-term outcomes in patients surgically treated for T4 CRC. All consecutive patients who underwent the resection of T4 CRC at a single centre from 2004 to 2013 were retrospectively analysed from a prospectively maintained database. POCs were assessed using the Clavien-Dindo classification. Patients who developed POCs were compared with those who did not in terms of recurrence-free survival (RFS) and overall survival (OS). The study population comprised 106 patients, including 79 (74.5%) with synchronous distant metastases. Overall, 46 patients (43%) developed at least one POC during the hospital stay, and of those patients, 9 (20%) had severe complications (Clavien-Dindo ≥ grade III). POCs were not associated with OS (65% with POCs vs. 69% without POCs; p = 0.72) or RFS (58% with POCs vs. 70% without POCs; p = 0.37). Similarly, POCs did not affect OS or RFS in patients who had synchronous metastases at diagnosis compared with those who did not. POCs do not affect the oncological course of patients subjected to the resection of T4 CRC, even in cases of synchronous metastases.