Details

Autor(en) / Beteiligte

• Gamradt, Stefanie
• Hasselmann, Helge
• Taenzer, Aline
• Brasanac, Jelena
• Stiglbauer, Victoria
• Sattler, Arne
• Sajitz-Hermstein, Max
• Kierszniowska, Sylwia
• Ramien, Caren
• Nowacki, Jan
• Mascarell-Maricic, Lea
• Wingenfeld, Katja
• Piber, Dominique
• Ströhle, Andreas
• Kotsch, Katja
• Paul, Friedemann
• Otte, Christian
• Gold, Stefan M.

Titel

Reduced mitochondrial respiration in T cells of patients with major depressive disorder

Ist Teil von

• iScience, 2021-11, Vol.24 (11), p.103312-103312, Article 103312

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Converging evidence indicates that major depressive disorder (MDD) and metabolic disorders might be mediated by shared (patho)biological pathways. However, the converging cellular and molecular signatures remain unknown. Here, we investigated metabolic dysfunction on a systemic, cellular, and molecular level in unmedicated patients with MDD compared with matched healthy controls (HC). Despite comparable BMI scores and absence of cardiometabolic disease, patients with MDD presented with significant dyslipidemia. On a cellular level, T cells obtained from patients with MDD exhibited reduced respiratory and glycolytic capacity. Gene expression analysis revealed increased carnitine palmitoyltransferase IA (CPT1a) levels in T cells, the rate-limiting enzyme for mitochondrial long-chain fatty acid oxidation. Together, our results indicate metabolic dysfunction in unmedicated, non-overweight patients with MDD on a systemic, cellular, and molecular level. This evidence for reduced mitochondrial respiration in T cells of patients with MDD provides translation of previous animal studies regarding a putative role of altered immunometabolism in depression pathobiology. [Display omitted] •MDD patients display signs of metabolic imbalance on a systemic level•Mitochondrial respiration and glycolysis are decreased in T cells of MDD patients•Key cellular metabolic markers negatively correlate with depression severity•Increased expression of CPT1a in T cells correlates with many serum metabolites Cellular neuroscience; Immunology; Metabolomics