Journal of translational medicine, 2019-05, Vol.17 (1), p.142-142, Article 142
2019
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Details
- Autor(en) / Beteiligte
- Titel
- Mesenchymal stem cell therapy targeting mitochondrial dysfunction in acute kidney injury
- Ist Teil von
- Journal of translational medicine, 2019-05, Vol.17 (1), p.142-142, Article 142
- Ort / Verlag
- England: BioMed Central Ltd
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Mitochondria take part in a network of cellular processes that regulate cell homeostasis. Defects in mitochondrial function are key pathophysiological changes during acute kidney injury (AKI). Mesenchymal stem cells (MSCs) have shown promising regenerative effects in experimental AKI models, but the specific mechanism is still unclear. Some studies have demonstrated that MSCs are able to target mitochondrial dysfunction during AKI. In this review, we summarize these articles, providing an integral and updated view of MSC therapy targeting mitochondrial dysfunction during AKI, which is aimed at promoting the therapeutic effect of MSCs in AKI patients.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1479-5876eISSN: 1479-5876DOI: 10.1186/s12967-019-1893-4Titel-ID: cdi_doaj_primary_oai_doaj_org_article_9519c065dd414c939edeb896068f49d1
- Format
- –
- Schlagworte
- Acute kidney failure, Acute kidney injury, Acute Kidney Injury - pathology, Acute Kidney Injury - physiopathology, Acute Kidney Injury - therapy, Adenosine triphosphate, Animals, Apoptosis, Bioenergetics, Biosynthesis, Care and treatment, Cytochrome, Development and progression, Homeostasis, Humans, Ischemia, Kidneys, Mesenchymal Stem Cell Transplantation, Mesenchymal stem cells, Mesenchymal Stem Cells - cytology, Mesenchyme, Metabolism, Mitochondria, Mitochondria - pathology, Mitochondria - ultrastructure, Mitochondrial diseases, Mitochondrial dysfunction, Mitophagy, Models, Biological, Oxidative stress, Pathogenesis, Permeability, Physiological aspects, Review, Sepsis, Stem cell transplantation, Stem cells, Systematic review