Details

Autor(en) / Beteiligte

• Marques, Cíntia
• Som, Claudia
• Schmutz, Mélanie
• Borges, Olga
• Borchard, Gerrit

Titel

How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept

Ist Teil von

• Frontiers in bioengineering and biotechnology, 2020-03, Vol.8, p.165-165

Ort / Verlag

Switzerland: Frontiers Media S.A

Erscheinungsjahr

2020

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Efficacy and safety of nanomedicines based on polymeric (bio)materials will benefit from a rational implementation of a Safe-by-Design (SbD) approach throughout their development. In order to achieve this goal, however, a standardization of preparation and characterization methods and their accurate reporting is needed. Focusing on the example of chitosan, a biopolymer derived from chitin and frequently used in drug and vaccine delivery vector preparation, this review discusses the challenges still to be met and overcome prior to a successful implementation of the SbD approach to the preparation of chitosan-based protein drug delivery systems.