Details

Autor(en) / Beteiligte

• Wolters, Manuel
• Frickmann, Hagen
• Christner, Martin
• Both, Anna
• Rohde, Holger
• Oppong, Kwabena
• Akenten, Charity Wiafe
• May, Jürgen
• Dekker, Denise

Titel

Molecular Characterization of Staphylococcus aureus Isolated from Chronic Infected Wounds in Rural Ghana

Ist Teil von

• Microorganisms (Basel), 2020-12, Vol.8 (12), p.2052

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2020

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Globally, is an important bacterial pathogen causing a wide range of community and hospital acquired infections. In Ghana, resistance of to locally available antibiotics is increasing but the molecular basis of resistance and the population structure of in particular in chronic wounds are poorly described. However, this information is essential to understand the underlying mechanisms of resistance and spread of resistant clones. We therefore subjected 28 isolates from chronic infected wounds in a rural area of Ghana to whole genome sequencing. Overall, resistance of to locally available antibiotics was high and 29% were Methicillin resistant (MRSA). The most abundant sequence type was ST88 (29%, 8/28) followed by ST152 (18%, 5/28). All ST88 carried the gene, which was associated with this sequence type only. Chloramphenicol resistance gene was exclusively associated with the methicillin-resistant ST88 strains. Panton-Valentine leukocidin (PVL) carriage was associated with ST121 and ST152. Other detected mechanisms of resistance included , conferring resistance to trimethoprim. This study provides valuable information for understanding the population structure and resistance mechanisms of isolated from chronic wound infections in rural Ghana.