Details

Autor(en) / Beteiligte

• Pellegrinelli, Laura
• Galli, Cristina
• Giardina, Federica
• Ferrari, Guglielmo
• Uceda Renteria, Sara Colonia
• Ceriotti, Ferruccio
• Seiti, Arlinda
• Binda, Sandro
• Pitrolo, Antonino Maria Guglielmo
• Schiavo, Roberta
• Malandrin, Sergio Maria Ivano
• Cavallero, Annalisa
• Arosio, Marco
• Farina, Claudio
• Oggioni, Massimo
• Congedo, Pierluigi
• Cereda, Danilo
• Rovida, Francesca
• Piralla, Antonio
• Pariani, Elena
• Baldanti, Fausto

Titel

Increased circulation of echovirus 11 in the general population and hospital patients as elicited by the non-polio enterovirus laboratory-based sentinel surveillance in northern Italy, 2023

Ist Teil von

• International journal of infectious diseases, 2024-05, Vol.142, p.106998-106998, Article 106998

Ort / Verlag

Canada: Elsevier Ltd

Erscheinungsjahr

2024

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• •Laboratory-based enterovirus surveillance detected an outbreak of echovirus 11.•Echovirus 11 only infected children; neonates were the most severely affected.•Echovirus 11 strains belonged to the D5 genogroup.•Echovirus 11 strains were related to the lineage circulating in Europe in 2022-23. Following the alert of echovirus 11 (E-11) infection in neonates in EU/EEA Member States, we conducted an investigation of E-11 circulation by gathering data from community and hospital surveillance of enterovirus (EV) in northern Italy from 01 August 2021 to 30 June 2023. Virological results of EVs were obtained from the regional sentinel surveillance database for influenza-like illness (ILI) in outpatients, and from the laboratory database of ten hospitals for inpatients with either respiratory or neurological symptoms. Molecular characterization of EVs was performed by sequence analysis of the VP1 gene. In our ILI series, the rate of EV-positive specimens showed an upward trend from the end of May 2023, culminating at the end of June, coinciding with an increase in EV-positive hospital cases. The E-11 identified belonged to the D5 genogroup and the majority (83%) were closely associated with the novel E-11 variant, first identified in severe neonatal infections in France since 2022. E-11 was identified sporadically in community cases until February 2023, when it was also found in hospitalized cases with a range of clinical manifestations. All E-11 cases were children, with 14 out of 24 cases identified through hospital surveillance. Of these cases, 60% were neonates, and 71% had severe clinical manifestations. Baseline epidemiological data collected since 2021 through EV laboratory-based surveillance have rapidly tracked the E-11 variant since November 2022, alongside its transmission during the late spring of 2023.