Details

Autor(en) / Beteiligte

• Sridhar, Siddharth
• Yip, Cyril C Y
• Wu, Shusheng
• Cai, Jianpiao
• Zhang, Anna Jin-Xia
• Leung, Kit-Hang
• Chung, Tom W H
• Chan, Jasper F W
• Chan, Wan-Mui
• Teng, Jade L L
• Au-Yeung, Rex K H
• Cheng, Vincent C C
• Chen, Honglin
• Lau, Susanna K P
• Woo, Patrick C Y
• Xia, Ning-Shao
• Lo, Chung-Mau
• Yuen, Kwok-Yung

Titel

Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant

Ist Teil von

• Emerging infectious diseases, 2018-12, Vol.24 (12), p.2241-2250

Ort / Verlag

United States: U.S. National Center for Infectious Diseases

Erscheinungsjahr

2018

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• All hepatitis E virus (HEV) variants reported to infect humans belong to the species Orthohepevirus A (HEV-A). The zoonotic potential of the species Orthohepevirus C (HEV-C), which circulates in rats and is highly divergent from HEV-A, is unknown. We report a liver transplant recipient with hepatitis caused by HEV-C infection. We detected HEV-C RNA in multiple clinical samples and HEV-C antigen in the liver. The complete genome of the HEV-C isolate had 93.7% nt similarity to an HEV-C strain from Vietnam. The patient had preexisting HEV antibodies, which were not protective against HEV-C infection. Ribavirin was an effective treatment, resulting in resolution of hepatitis and clearance of HEV-C viremia. Testing for this zoonotic virus should be performed for immunocompromised and immunocompetent patients with unexplained hepatitis because routine hepatitis E diagnostic tests may miss HEV-C infection. HEV-C is also a potential threat to the blood product supply.