Signal transduction and targeted therapy, 2022-01, Vol.7 (1), p.3-3, Article 3
2022
Details
- Autor(en) / Beteiligte
- Titel
- Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
- Ist Teil von
- Signal transduction and targeted therapy, 2022-01, Vol.7 (1), p.3-3, Article 3
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2022
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases. Although many articles have reviewed Wnt/β-catenin from various aspects, a systematic review encompassing the origin, composition, function, and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking. In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research. Finally, we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2059-3635, 2095-9907eISSN: 2059-3635DOI: 10.1038/s41392-021-00762-6Titel-ID: cdi_doaj_primary_oai_doaj_org_article_910400280fd140a69090e0dab18737eb
- Format
- –
- Schlagworte
- Animals, beta Catenin - genetics, beta Catenin - metabolism, Cancer, Cell growth, Clinical trials, Embryogenesis, Endoplasmic reticulum, Genes, Homeostasis, Humans, Kinases, Ligands, Lipids, Metabolism, Neoplasm Proteins - genetics, Neoplasm Proteins - metabolism, Neoplasms - genetics, Neoplasms - metabolism, Phosphorylation, Plasma, Proteins, Regulation, Review, Signal transduction, Tumors, Wnt protein, Wnt Proteins - genetics, Wnt Proteins - metabolism, Wnt Signaling Pathway, β-Catenin