Details

Autor(en) / Beteiligte

• Li, Zhi-Hao
• Wang, Xiao-Meng
• Liao, Dan-Qing
• Zhang, Qian
• Chen, Zi-Ting
• Qiu, Cheng-Shen
• Tang, Xu-Lian
• Li, Hong-Min
• Du, Li-Ying
• Zhang, Pei-Dong
• Shen, Dong
• Zhang, Xi-Ru
• Gao, Jian
• Zhong, Wen-Fang
• Chen, Pei-Liang
• Huang, Qing-Mei
• Song, Wei-Qi
• Liu, Dan
• Li, Chuan
• Chen, Huan
• Mao, Chen

Titel

Long-term air pollutants exposure and respiratory mortality: A large prospective cohort study

Ist Teil von

• Ecotoxicology and environmental safety, 2024-04, Vol.274, p.116176-116176, Article 116176

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

2024

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Ambient air pollution is a major global health concern. Yet, no study has thoroughly assessed its link to respiratory mortality. Our research evaluated the combined and individual effects of air pollutants on respiratory mortality risks based on the UK Biobank. A total of 366,478 participants were studied. A Cox proportional hazards model was used to estimate the respiratory mortality risk from combined long-term exposure to five pollutants, summarized as a weighted air pollution score. During a median of 13.6 years of follow-up, 6113 deaths due to respiratory diseases were recorded. The hazard ratios (HRs) and 95% confidence intervals (95% CIs) of respiratory diseases were 2.64 (2.05–3.39), 1.62 (1.23–2.12), 2.06 (1.73–2.45), 1.20 (1.16–1.25), and 1.07 (1.05–1.08) per 10 μg/m3 increase in PM2.5, PM2.5–10, PM10, NO2, and NOx, respectively. The air pollution score showed a dose-response association with an elevated respiratory mortality risk. The highest versus lowest quartile air pollution score was linked to a 44% increase in respiratory mortality risk (HR 1.44, 95% CI: 1.33–1.57), with consistent findings in subgroup and sensitivity analyses. Long-term individual and joint air-pollutant exposure showed a dose-response association with an increased respiratory mortality risk, highlighting the importance of a comprehensive air-pollutant assessment to protect public health. [Display omitted] •Air pollution is a risk factor for respiratory mortality.•Long-term exposure to air pollution increased respiratory mortality risk.•The AP score showed a dose-response association with respiratory mortality risk.