Details

Autor(en) / Beteiligte

• Hoffmann, Thomas J.
• Passarelli, Michael N.
• Graff, Rebecca E.
• Emami, Nima C.
• Sakoda, Lori C.
• Jorgenson, Eric
• Habel, Laurel A.
• Shan, Jun
• Ranatunga, Dilrini K.
• Quesenberry, Charles P.
• Chao, Chun R.
• Ghai, Nirupa R.
• Aaronson, David
• Presti, Joseph
• Nordström, Tobias
• Wang, Zhaoming
• Berndt, Sonja I.
• Chanock, Stephen J.
• Mosley, Jonathan D.
• Klein, Robert J.
• Middha, Mridu
• Lilja, Hans
• Melander, Olle
• Kvale, Mark N.
• Kwok, Pui-Yan
• Schaefer, Catherine
• Risch, Neil
• Van Den Eeden, Stephen K.
• Witte, John S.

Titel

Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer

Ist Teil von

• Nature communications, 2017-01, Vol.8 (1), p.14248-14248, Article 14248

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Prostate-specific antigen (PSA) levels have been used for detection and surveillance of prostate cancer (PCa). However, factors other than PCa—such as genetics—can impact PSA. Here we present findings from a genome-wide association study (GWAS) of PSA in 28,503 Kaiser Permanente whites and 17,428 men from replication cohorts. We detect 40 genome-wide significant ( P <5 × 10 −8 ) single-nucleotide polymorphisms (SNPs): 19 novel, 15 previously identified for PSA (14 of which were also PCa-associated), and 6 previously identified for PCa only. Further analysis incorporating PCa cases suggests that at least half of the 40 SNPs are PSA-associated independent of PCa. The 40 SNPs explain 9.5% of PSA variation in non-Hispanic whites, and the remaining GWAS SNPs explain an additional 31.7%; this percentage is higher in younger men, supporting the genetic basis of PSA levels. These findings provide important information about genetic markers for PSA that may improve PCa screening, thereby reducing over-diagnosis and over-treatment. Prostate-specific antigen is used as a biomarker of prostate cancer, but levels can be affected by other factors not related to cancer. Here, the authors find genes associated with prostate specific antigen levels in healthy men, which could be used to reduce over-diagnosis and over-treatment.