Details

Autor(en) / Beteiligte

• Paquola, Casey
• Bethlehem, Richard Ai
• Seidlitz, Jakob
• Wagstyl, Konrad
• Romero-Garcia, Rafael
• Whitaker, Kirstie J
• Vos de Wael, Reinder
• Williams, Guy B
• Vértes, Petra E
• Margulies, Daniel S
• Bernhardt, Boris
• Bullmore, Edward T

Titel

Shifts in myeloarchitecture characterise adolescent development of cortical gradients

Ist Teil von

• eLife, 2019-11, Vol.8

Ort / Verlag

England: eLife Science Publications, Ltd

Erscheinungsjahr

2019

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• We studied an accelerated longitudinal cohort of adolescents and young adults (n = 234, two time points) to investigate dynamic reconfigurations in myeloarchitecture. Intracortical profiles were generated using magnetization transfer (MT) data, a myelin-sensitive magnetic resonance imaging contrast. Mixed-effect models of depth specific intracortical profiles demonstrated two separate processes i) overall increases in MT, and ii) flattening of the MT profile related to enhanced signal in mid-to-deeper layers, especially in heteromodal and unimodal association cortices. This development was independent of morphological changes. Enhanced MT in mid-to-deeper layers was found to spatially co-localise specifically with gene expression markers of oligodendrocytes. Interregional covariance analysis revealed that these intracortical changes contributed to a gradual differentiation of higher-order from lower-order systems. Depth-dependent trajectories of intracortical myeloarchitectural development contribute to the maturation of structural hierarchies in the human neocortex, providing a model for adolescent development that bridges microstructural and macroscopic scales of brain organisation.