Details

Autor(en) / Beteiligte

• Karp, Natasha A
• Mason, Jeremy
• Beaudet, Arthur L
• Benjamini, Yoav
• Bower, Lynette
• Braun, Robert E
• Brown, Steve D M
• Chesler, Elissa J
• Dickinson, Mary E
• Flenniken, Ann M
• Fuchs, Helmut
• Angelis, Martin Hrabe de
• Gao, Xiang
• Guo, Shiying
• Greenaway, Simon
• Heller, Ruth
• Herault, Yann
• Justice, Monica J
• Kurbatova, Natalja
• Lelliott, Christopher J
• Lloyd, K C Kent
• Mallon, Ann-Marie
• Mank, Judith E
• Masuya, Hiroshi
• McKerlie, Colin
• Meehan, Terrence F
• Mott, Richard F
• Murray, Stephen A
• Parkinson, Helen
• Ramirez-Solis, Ramiro
• Santos, Luis
• Seavitt, John R
• Smedley, Damian
• Sorg, Tania
• Speak, Anneliese O
• Steel, Karen P
• Svenson, Karen L
• Wakana, Shigeharu
• West, David
• Wells, Sara
• Westerberg, Henrik
• Yaacoby, Shay
• White, Jacqueline K

Titel

Prevalence of sexual dimorphism in mammalian phenotypic traits

Ist Teil von

• Nature communications, 2017-06, Vol.8 (1), p.15475-15475, Article 15475

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.