Molecules (Basel, Switzerland), 2022-09, Vol.27 (19), p.6229
2022
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Details
- Autor(en) / Beteiligte
- Titel
- Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities
- Ist Teil von
- Molecules (Basel, Switzerland), 2022-09, Vol.27 (19), p.6229
- Ort / Verlag
- Basel: MDPI AG
- Erscheinungsjahr
- 2022
- Quelle
- EZB Electronic Journals Library
- Beschreibungen/Notizen
- Antimetabolites of folic acid represent a large group of drugs and drug candidates, including those for cancer chemotherapy. In this current review, the most common methods and approaches are presented for the synthesis of therapeutically significant antimetabolites of folic acid, which are Methotrexate (MTX), Raltitrexed (Tomudex, ZD1694), Pralatrexate, Pemetrexed, TNP-351, and Lometrexol. In addition, the applications or uses of these folic acid antimetabolites are also discussed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1420-3049eISSN: 1420-3049DOI: 10.3390/molecules27196229Titel-ID: cdi_doaj_primary_oai_doaj_org_article_903a2a0ca2054021bba44c85cea5aab8
- Format
- –
- Schlagworte
- Acids, Analysis, antifolates, Antimetabolites, Antimitotic agents, Antineoplastic agents, applications, Cancer therapies, Chemotherapy, Competition, Dihydrofolate reductase, Drug development, drugs, Enzymes, Folic acid, folic acids, Health aspects, Hydrocarbons, Metabolites, Methotrexate, Product development, Review, synthesis, Tomudex, Vitamin B