Virology journal, 2022-12, Vol.19 (1), p.209-209, Article 209
2022
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- Autor(en) / Beteiligte
- Titel
- Discovery of vaccine-like recombinant SARS-CoV-2 circulating in human
- Ist Teil von
- Virology journal, 2022-12, Vol.19 (1), p.209-209, Article 209
- Ort / Verlag
- England: BioMed Central Ltd
- Erscheinungsjahr
- 2022
- Quelle
- SpringerLink
- Beschreibungen/Notizen
- For viral diseases, vaccination with live attenuated vaccine (LAV) is one of the most effective means for fighting the diseases. However, LAV occasionally overflows from vaccinated individuals circulate in the population with unforeseen consequences. Currently, SARS-CoV-2 LAVs are undergoing clinical trials. In this study, we found that the viruses isolated from Indian SARS CoV-2 infected persons may be candidate LAV-derived strains, indicating the risk of SARS-CoV-2 LAV spillover from vaccinated persons, increasing the complexity of SARS-CoV-2 detection. In addition, the property of frequent recombination of SARS-CoV-2 increases the chance of LAV virulence reversion. Therefore, how to distinguish the LAV viruses from the wild strain and how to avoid the recombination of the circulating vaccine strain and the wild strain are the challenges currently faced by SARS CoV-2 LAV development.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1743-422XeISSN: 1743-422XDOI: 10.1186/s12985-022-01945-5Titel-ID: cdi_doaj_primary_oai_doaj_org_article_8eb0c8ff84c2406f916a2407fb1f7728
- Format
- –
- Schlagworte
- Amino acids, Antigens, Brief Report, Clinical trials, Coronaviruses, COVID-19 - prevention & control, COVID-19 vaccines, Enzymes, Genetic engineering, Genomes, Humans, Maximum likelihood method, Microbial mutation, Mutation, Pathogens, Phylogenetics, Proteins, Recombination, Reversion, RNA polymerase, SARS-CoV-2 - genetics, Severe acute respiratory syndrome coronavirus 2, Software packages, Vaccination, Vaccines, Viral diseases, Virulence, Virus research, Viruses