Details

Autor(en) / Beteiligte

• Pavlik, Edward J
• Smith, Christopher
• Dennis, Taylor S
• Harvey, Elizabeth
• Huang, Bin
• Chen, Quan
• Piecoro, Dava West
• Burgess, Brian T
• McDowell, Anthony
• Gorski, Justin
• Baldwin, Lauren A
• Miller, Rachel W
• DeSimone, Christopher P
• Dietrich, 3rd, Charles
• Gallion, Holly H
• Ueland, Frederick R
• van Nagell, Jr, John R

Titel

Disease-Specific Survival of Type I and Type II Epithelial Ovarian Cancers-Stage Challenges Categorical Assignments of Indolence & Aggressiveness

Ist Teil von

• Diagnostics (Basel), 2020-01, Vol.10 (2), p.56

Ort / Verlag

Switzerland: MDPI

Erscheinungsjahr

2020

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Epithelial ovarian cancers (EOC) consist of several sub-types based on histology, clinical, molecular and epidemiological features that are termed "histo-types", which can be categorized into less aggressive Type I and more aggressive Type II malignancies. This investigation evaluated the disease-specific survival (DSS) of women with Type I and II EOC using histo-type, grade, and stage. A total of 200,658 EOC cases were identified in the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) data. Kaplan-Meier survival analyses, one-factor ANOVA and Chi-square analyses were performed on 10-year DSS survivals. DSS strongly supported a 2-tiered classification (grade 1 vs. grade 2 & 3) for serous EOC. DSS of early stage serous EOC for grade 2 was significantly different from grade 3 indicating that a 2-tier classification for serous EOC applied only to late stage. DSS of Type I EOC was much better than Type II. However, DSS was 46-58% lower with late stage Type I than with early stage Type I indicating that Type I ovarian cancers should not be considered indolent. Early stage Type II EOC had much better DSS than late stage Type II stressing that stage has a large role in survival of both Type I and II EOC.