OncoTargets and therapy, 2016-01, Vol.9, p.6203-6210
2016
Details
- Autor(en) / Beteiligte
- Titel
- miR-203 facilitates tumor growth and metastasis by targeting fibroblast growth factor 2 in breast cancer
- Ist Teil von
- OncoTargets and therapy, 2016-01, Vol.9, p.6203-6210
- Ort / Verlag
- New Zealand: Dove Medical Press Limited
- Erscheinungsjahr
- 2016
- Link zum Volltext
- Quelle
- Taylor & Francis Journals Auto-Holdings Collection
- Beschreibungen/Notizen
- Breast cancer is the second leading cause of cancer mortality in women worldwide. Molecular therapy is needed to improve the outcome in patients with breast cancer. miR-203 participates in cancer cell proliferation, transformation, and apoptosis. This study showed that miR-203 was upregulated in breast cancer tissues and the MCF-7 cell line. miR-203 knockdown suppressed colony formation and transformation and also limited migration in MCF-7 cells. Fibroblast growth factor 2 (FGF2) was confirmed as a novel target of miR-203, as miR-203 knockdown induced an enhanced expression of FGF2 in MCF-7 cells. Moreover, FGF2 can reverse transforming growth factor-β signal pathway to suppress breast cancer. These findings provide new insights with potential therapeutic applications for the treatment of breast cancer.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1178-6930eISSN: 1178-6930DOI: 10.2147/ott.s108712Titel-ID: cdi_doaj_primary_oai_doaj_org_article_8c3960b44b6b424da28eeba306ac48b5
- Format
- –
- Schlagworte
- Apoptosis, Binding sites, Breast cancer, Care and treatment, Cell cycle, Cell growth, Development and progression, FGF2, Fibroblast growth factors, Fibroblasts, Gene expression, Genetic aspects, Growth factors, Health aspects, Hospitals, Innovations, Kinases, Lung cancer, Metastasis, MicroRNA, MicroRNAs, miR-203, Molecular targeted therapy, Mortality, Original Research, Pathogenesis, Prostate, Transforming growth factor-b, Wound healing