Details

Autor(en) / Beteiligte

• Wang, Yangyang
• Qu, Kuo
• Lu, Wenting
• Zhao, Peiyan
• Wang, Zhe
• Cui, Cuiyun
• Liu, Ye
• Yang, Ming
• Yu, Yongli
• Wang, Liying

Titel

Neutrophils recruited to immunization sites initiating vaccine-induced antibody responses by locally expressing BAFF

Ist Teil von

• iScience, 2022-06, Vol.25 (6), p.104453-104453, Article 104453

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Neutrophils played a key role in the innate immune responses. Less is known about whether and how the neutrophils recruited in the immunization sites affecting the vaccine-induced antibody responses. In the process of evaluating the efficacy of an oil-in-water emulsion-formulated vaccine in mice, we found that neutrophils were rapidly and massively recruited to immunization sites but were barely detected in the draining lymph nodes. Interestingly, B cell-activating factor (BAFF) was abundantly expressed in the recruiting neutrophils at a very early stage. The initial neutrophil-derived BAFF firstly brought about the B cell responses in the local part, then subsequently in lymphoid organs. Activated B cells produced more BAFF through TLR9-IRF5 signaling pathway, thereby amplifying the vaccine-induced antibody responses. Suppressing BAFF in the neutrophils could weaken the B cell activation and reduce the antibody production. The data indicate that vaccines endow neutrophils with the potential to orchestrate antibody responses at immunization sites. [Display omitted] •Neutrophils at immunization sites influencing subsequent immune responses•Neutrophil-driven BAFF at immunization sites assisting B cell responses to vaccines•Activated B cells produce more BAFF through TLR9-IRF5 signaling pathway•BAFF-producing neutrophils orchestrate antibody responses at immunization sites Components of the immune system; Immune response; Immunology