Details

Autor(en) / Beteiligte

• Khusainova, Alina I.
• Nizamutdinov, Alexey S.
• Shamsutdinov, Nail I.
• Kalinichenko, Svetlana
• Safin, Damir I.
• Gafurov, Marat
• Lukinova, Elena V.
• Batygov, Sergey Kh
• Kuznetsov, Sergey V.
• Zinchenko, Sergey V.
• Zelenikhin, Pavel V.
• Pudovkin, Maksim

Titel

Photo- and X-ray Induced Cytotoxicity of CeF3-YF3-TbF3 Nanoparticle-Polyvinylpyrrolidone—“Radachlorin” Composites for Combined Photodynamic Therapy

Ist Teil von

• Materials, 2024-01, Vol.17 (2), p.316

Ort / Verlag

Basel: MDPI AG

Erscheinungsjahr

2024

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The Ce0.5Y0.35Tb0.15F3 nanoparticles with a CeF3 hexagonal structure were synthesized using the co-precipitation technique. The average nanoparticle diameter was 14 ± 1 nm. The luminescence decay curves of the Ce0.5Y0.35Tb0.15F3 nanoparticles (λem = 541 nm, 5D4–7F5 transition of Tb3+) conjugated with Radachlorin using polyvinylpyrrolidone coating as well as without Radachlorin were detected. Efficient nonradiative energy transfer from Tb3+ to the Radachlorin was demonstrated. The maximum energy transfer coefficients for the nanoparticles conjugated with Radachlorin via polyvinylpyrrolidone and without the coating were 82% and 55%, respectively. The average distance between the nanoparticle surface and Radachlorin was R0 = 4.5 nm. The best results for X-ray-induced cytotoxicity were observed for the NP-PVP-Rch sample at the lowest Rch concentration. In particular, after X-ray irradiation, the survival of A549 human lung carcinoma cells decreased by ~12%.