Frontiers in human neuroscience, 2022-06, Vol.16, p.924155
2022
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Details
- Autor(en) / Beteiligte
- Titel
- The Role of Brain-Derived Neurotrophic Factor Signaling in Central Nervous System Disease Pathogenesis
- Ist Teil von
- Frontiers in human neuroscience, 2022-06, Vol.16, p.924155
- Ort / Verlag
- Lausanne: Frontiers Research Foundation
- Erscheinungsjahr
- 2022
- Quelle
- EZB Electronic Journals Library
- Beschreibungen/Notizen
- Recent studies have found abnormal levels of brain-derived neurotrophic factor (BDNF) in a variety of central nervous system (CNS) diseases (e.g., stroke, depression, anxiety, Alzheimer’s disease, and Parkinson’s disease). This suggests that BDNF may be involved in the pathogenesis of these diseases. Moreover, regulating BDNF signaling may represent a potential treatment for such diseases. With reference to recent research papers in related fields, this article reviews the production and regulation of BDNF in CNS and the role of BDNF signaling disorders in these diseases. A brief introduction of the clinical application status of BDNF is also provided.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1662-5161eISSN: 1662-5161DOI: 10.3389/fnhum.2022.924155Titel-ID: cdi_doaj_primary_oai_doaj_org_article_8be50c002f7a4a39b7acbe4d0bc8fdd8
- Format
- –
- Schlagworte
- Alzheimer's disease, anxiety, Apoptosis, Brain research, Brain-derived neurotrophic factor, Central nervous system, Central nervous system diseases, depression, Emotional disorders, Endoplasmic reticulum, Kinases, Medical prognosis, Mental depression, Mood disorders, Movement disorders, Nervous system, neurodegenerative disease, Neurodegenerative diseases, Neurogenesis, Neurons, Neuroscience, Parkinson's disease, Pathogenesis, Physiology, Proteins, Signal transduction, stroke, Traumatic brain injury, TrkB