Details

Autor(en) / Beteiligte

• Blouin, Yann
• Cazajous, Géraldine
• Dehan, Céline
• Soler, Charles
• Vong, Rithy
• Hassan, Mohamed Osman
• Hauck, Yolande
• Boulais, Christian
• Andriamanantena, Dina
• Martinaud, Christophe
• Martin, Émilie
• Pourcel, Christine
• Vergnaud, Gilles

Titel

Progenitor “Mycobacterium canettii” clone responsible for lymph node tuberculosis epidemic, Djibouti

Ist Teil von

• Emerging infectious diseases, 2014-01, Vol.20 (1), p.21-28

Ort / Verlag

United States: U.S. National Center for Infectious Diseases

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• “Mycobacterium canettii,” an opportunistic human pathogen living in an unknown environmental reservoir, is the progenitor species from which Mycobacterium tuberculosis emerged. Since its discovery in 1969, most of the ≈70 known M. canettii strains were isolated in the Republic of Djibouti, frequently from expatriate children and adults. We show here, by whole-genome sequencing, that most strains collected from February 2010 through March 2013, and associated with 2 outbreaks of lymph node tuberculosis in children, belong to a unique epidemic clone within M. canettii. Evolution of this clone, which has been recovered regularly since 1983, may mimic the birth of M. tuberculosis. Thus, recognizing this organism and identifying its reservoir are clinically important.